Oseltamivir for influenza

Oseltamivir-Resistant Influenza A Viruses

Oseltamivir-resistant pandemic H1N1 influenza.

E420 CMAJ, April 19, 2011, 183(7) © 2011 Canadian Medical Association or its licensors In December 2009, a 27-year-old man with severe influenza-like illness was admitted to a tertiary care hospital in Saint John, New Brunswick. The patient had asthma, obesity (body mass index 40.7 kg/m) and untreated familial hypercholesterolemia. He had not received immunization against pandemic H1N1 influenz...

Oral oseltamivir treatment of influenza in children.

BACKGROUND Oral oseltamivir administration is effective treatment for influenza in adults. This study was conducted to determine the efficacy, safety and tolerability of oseltamivir in children with influenza. METHODS In this randomized, double blind, placebo-controlled study, children 1 through 12 years with fever [> or =100 degrees F (> or =38 degrees C)] and a history of cough or coryza <4...

Influenza virus susceptibility and resistance to oseltamivir.

Oseltamivir phosphate is a prodrug of oseltamivir carboxylate, a highly specific inhibitor of influenza virus neuraminidases. Given that oseltamivir carboxylate binds to highly conserved, essential amino acids in the catalytic site of the enzyme, and that the activity of neuraminidase is critical for virus release from infected cells and subsequent virus spread, the drug was expected to have a ...

Global transmission of oseltamivir-resistant influenza.

953 S from one influenza season to the next, we have lost the use of our leading antiviral influenza drug because of resistance. This winter, the circulating strain of seasonal influenza A virus (H1N1) is resistant to the neuraminidase inhibitor osel tamivir. Moreover, rather than emerging under selective pressure of drug use, as many antibiotic-resistant bacteria do and as has been the concern...